Partial replication of two rumination-related candidate gene studies

Studies on the replication of African Horse Sickness Virus in two different cell line cultures

Hypospadias: Gene Mapping and Candidate Gene Studies

Hypospadias is a common congenital malformation in boys, characterized by incomplete fusion of the urethral folds, abnormal opening of urethra and different degrees of curvature of the penis. In Sweden, the incidence of hypospadias is 1.14 per 300 male live-births according to the annual Swedish Malformation Registry. Hypospadias is considered to be a complex genetic disorder caused by the inte...

Candidate gene association studies: successes and failures.

Epidemiologic studies of twins indicate that 20-40% of common tumors such as breast, colorectal, and prostate cancers are inherited. However, the effect of high penetrance tumor susceptibility genes such as APC, BRCA1, BRAC2, MSH1, MLH2 and MSH6 only accounts for a small fraction of these cancers. Low to moderate penetrance tumor susceptibility genes likely account for the large remaining propo...

Editorial Policy for Candidate Gene Studies

The Journal of Abnormal Child Psychology receives an increasing number of manuscripts reporting tests of associations of candidate genetic polymorphisms with measures of psychopathology in children and adolescents, including tests of gene-environment interactions. These studies represent the exciting new directions that research in child psychopathology is taking. However, the studies also repr...

Editorial policy on candidate gene association and candidate gene-by-environment interaction studies of complex traits.

The literature on candidate gene associations is full of reports that have not stood up to rigorous replication. This is the case both for straightforward main effects and for candidate gene-by-environment interactions (Duncan and Keller 2011). As a result, the psychiatric and behavior genetics literature has become confusing and it now seems likely that many of the published findings of the la...